Publications
I. Botezatu, G. Potapova, V. Shelepov, R. Alechina, S. Arsenin, H. Melkonyan, S. Umansky, and A. Lichtenstein.
Genetic analysis of DNA excreted in urine: A new approach for detecting specific genomic DNA sequences from cells dying in an organism. Clin. Chem. 46: 1078-1084 (2000).
A.V. Lichtenstein, O.I. Serdjuk, T.I. Sukhova, H.S. Melkonyan, and S.R. Umansky.
Selective "stencil"-aided pre-PCR cleavage of wild type sequences as a novel approach to detection of mutant K-RAS. Nucl. Acid Res. 29: e90 (2001).
A.V. Lichtenstein, H.S. Melkonyan, L.D. Tomei, and S.R. Umansky.
Circulating nucleic acids and apoptosis. Ann. New York Acad. Sci. 945: 239-249 (2001).
A.V. Lichtenstein, H.S. Melkonyan, and S.R. Umansky.
Circulating DNA analysis: Possible universal method for early tumor detection and preventive screening. In Molecular Testing in Laboratory Medicine (David Bruns, Y.M. Dennis Lo, and Carl Wittwer, Eds.) AACC Press, pp. 300-308 (2002).
Y.-H. Su, M. Wang, D.E. Brenner, A. Ng, H. Melkonyan, S.R. Umansky, S. Syngal, and T.M. Block.
Human urine contains small, 150-250 nucleotide sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer. J. Mol. Diagn. 6: 101-107 (2004).
Y.-H. Su, M. Wang, T.M. Block, O. Landt, I. Botezatu, O. Serdyuk, A. Lichtenstein, H. Melkonyan, L.D. Tomei, and S. Umansky.
Transrenal DNA as a diagnostic tool: important technical notes. Ann. New York Acad. Sci. 1022: 81-89 (2004).
A.V. Lichtenstein, H.S. Melkonyan, L.D. Tomei, and S.R. Umansky.
Novel applications of PCR to urinary nucleic acid analysis. In Methods in Molecular Biology, v. 336: Clinical Applications of PCR. (Y.M. D. Lo, R.W.K. Chiu, and K.C.A. Chan, Eds.) Humana Press Inc, Totowa, NJ, pp. 145-154 (2006).
S.R. Umansky and L.D.Tomei.
Transrenal DNA testing: progress and perspectives. Expert Rev. Mol. Diagn. 6: 153-163 (2006).
Y.-H. Su, M. Wang, B. Aiamkitsumrit, D.E. Brenner, and T.M. Block.
Detection of a K-ras mutation in urine of patients with colorectal cancer. Cancer Biomarkers 1: 177–182 (2005).
K. Koide, A. Sekizawa, M. Iwasaki, R. Matsuoka, S. Honma, A. Farina, H. Saito, and T. Okai.
Fragmentation of cell-free fetal DNA in plasma and urine of pregnant women. Prenat. Diagn. 25: 604-607 (2005).
L.D. Tomei, A. Cannas, G. Fimia, A. Amendola, H. Melkonyan, and S.R. Umansky.
Detection of cell-free proviral HIV DNA in urine of AIDS patients. Proc XIX Internatl Congr Clin Chem IFCC/AACC July 24-28, 2005.
M. Fambrini, C. Penna, A. Pieralli, C. Bussani, M.G. Fallani, K.L. Andersson, G. Scarselli, and M. Marchionni.
PCR detection rates of high risk human papillomavirus DNA in paired self-collected urine and cervical scrapes after laser CO2 conization for high-grade cervical intraepithelial neoplasia. Gynecol. Oncol. 109: 59-64 (2008).
E. Jong, J.W. Mulder, E.C. van Gorp, J.K. Wagenaar, J. Derksen, J. Westerga, A. Tol, and P.H. Smits.
The prevalence of human papillomavirus (HPV) infection in paired urine and cervical smear samples of HIV-infected women. J Clin Virol. 41: 111-115 (2008).
A. Cannas, D. Goletti, E. Girardi, T. Chiacchio, L. Calvo, G. Cuzzi, M. Piacentini, H. Melkonyan, S.R. Umansky, F.N. Lauria, G. Ippolito, and L.D. Tomei.
Mycobacterium tuberculosis DNA detection in soluble fraction of urine from pulmonary tuberculosis patients. Int. J. Tuberc. Lung Dis. 12: 146-151 (2008).
K.C. Chan, S.F. Leung, S.W. Yeung, A.T. Chan, and Y.M. Lo.
Quantitative analysis of the transrenal excretion of circulating EBV DNA in nasopharyngeal carcinoma patients. Clin. Cancer Res. 14: 4809-4813 (2008).
Y.-H. Su, M. Wang, D.E. Brenner, P.A. Norton, and T.M. Block.
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. Ann. New York Acad. Sci. 1137: 197-206 (2008).
Y.-H. Su, Z. Wang, X.H. Wang, M. Wang, D.E. Brenner, and T.M. Block.
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine. Ann. New York Acad. Sci. 1137: 82-91 (2008).
H.S. Melkonyan, W.J. Feaver, E. Meyer, V. Scheinker, E.M. Shekhtman, Z. Xin, and S.R. Umansky.
Transrenal nucleic acids: from proof of principle to clinical tests. Ann. New York Acad. Sci. 1137: 73-81 (2008).
E.M. Shekhtman, K. Anne, H.S. Melkonyan, D.J. Robbins, S.L. Warsof, and S.R. Umansky.
Optimization of Transrenal DNA analysis: detection of fetal DNA in maternal urine. Clin. Chem. (in press).
